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Similarly, inverse agonists of the cannabinoid-1 receptor have demonstrated favorable metabolic and structural outcomes in preclinical models, improving insulin sensitivity and maintaining renal architecture (239, 240)

10.1007/s40265-023-01939-9 [DOI] [PMC free article] [PubMed] [Google Scholar] Rehm J., Hasan O

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Looking at one study, even in fairly sensitive asthmatic patients only 4 of 24 had a reaction to extremely high sulfite levels (45mg dose from 300mg/L concentration)