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[149] Derived from Table 2 available on [150] History [edit] Between 1849 and 1887, Thomas Addison described a case of pernicious anemia, William Osler and William Gardner first described a case of neuropathy, Hayem described large red cells in the peripheral blood in this condition, which he called "giant blood corpuscles" (now called macrocytes), Paul Ehrlich identified megaloblasts in the bone marrow, and Ludwig Lichtheim described a case of myelopathy

HOMA2-IR returns in proportion to regain (about +0.6% at under-25% regain to +39.5% at 50-75%)

Low levels of vitamin B12 can lead to fatigue and anemia in milder cases

Pollard & Pomfrett suggest that DSIP administration doesnt induce tolerance,4 but theirs isnt the consensus conclusion

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