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Oral supplements are safer than injections but should be taken only after consulting a doctor

These products may increase heart rate and blood pressure, potentially exacerbating cardiovascular risks

10.1007/s10741-018-9749-1 119 PatelP.KarchJ

The regulation of the VHLHIF pathway is also related to iron metabolism and ferroptosis in ccRCC, as iron levels are significantly higher in RCC cells and the tumor microenvironment than in normal renal tissue (77), and as HIF-1 mediates the cellular upregulation of TfRC and heme oxygenase (HO) expression, promoting cellular iron accumulation (78, 79)

This distinction is important and helps explain why the relationship between folate and cancer is more complex than simple claims of benefit or harm