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This syndrome has been reported to be more likely if the patient has abnormal kidney function.9 Although there is some significant debate on this point10, it is generally agreed that patients with abnormal kidney function should start allopurinol at low doses and build up, to ensure that the allopurinol is effectively excreted

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The study, to be published in the Journal of Addiction, concluded: 'The sooner smokers get off this escalator of death the longer and healthier they can expect their lives to be.' Dr Sarah Jackson, principal research fellow from the UCL Alcohol and Tobacco Research Group, added: 'It is vital that people understand just how harmful smoking is and how quitting can improve their health and life expectancy