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The disruption of the vital enzymatic steps associated with glutamine utilization by glutaminase inhibitors results in reduced availability of metabolic intermediates required for nucleotide synthesis, tricarboxylic acid (TCA) cycle replenishment, and redox balance maintenance, collectively inducing metabolic stress and compromising cancer cell viability [56]

Therapy-induced senescence: an old friend becomes the enemy

Sodium is very important in intracellular pH maintenance for microbes because it allows exchange of H + /Na + antiporters into the culture media (Satyanarayana et al., 2005)

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