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J Biol Chem 1997, 272: 2264222647

One study demonstrated that gluconeogenic intermediates, such as pyruvate, malate, and phosphoenolpyruvate (PEP), are neuroprotective against MPP + toxicity

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At the same time, it can be drastically decreased if the person in question is obese and sedentary

In a Walsh-style review, the pattern may include high glutamate, NMDAR hyperactivity, high histamine, undermethylation, low zinc, high copper, pyroluria, oxidative stress, reduced glutathione, gut inflammation, or impaired methylation efficiency