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While the depletion of cysteine and the accumulation of cystine and Met-SO clearly indicate increased oxidative stress in SLE, none of these compounds or the unique PPP substrates R5P or S7P correlated with disease activity of untreated patients
However, translating a biochemical role into a predictable clinical result (like weight loss) requires strong human trial evidence, which is limited for MIC injection blends
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These findings actively support the importance of GPX4 in preventing activated Treg cells from ferroptosis and lipid peroxidation and suggest a potential therapeutic avenue to optimize cancer therapy
Disclosures Disclosure forms, as provided by each author, are available with the online version of the article at Author Contributions Conceptualization: Yuki Sugiura, Motoko Yanagita
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