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Simultaneously, studies have demonstrated that combined treatment of copper sulfate and hydroxylysine would additively or synergistically enhance collagen cross-linking in engineered articular cartilage, improving the tensile and biomechanical properties of the neocartilage (Makris et al., 2013)

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The pathophysiological mechanisms underlying glycine deficit and its potential clinical repercussions are not yet clear yet

Omega-3 fatty acids, known for their anti-inflammatory properties, have been shown to mitigate these effects by improving synaptic plasticity, enhancing neurogenesis, and potentially alleviating depression symptoms (27, 28)

A variation in t max was observed across the groups but with no apparent association with increasing hepatic impairment (45, 36, 84 and 45 h for normal hepatic function and mild, moderate and severe hepatic impairment, respectively)