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Those considering starting on B12 injections should understand these failure predictors to avoid wasting time with supplements that wont work

In some cases, a bone marrow biopsy may be necessary

The vitamin is an important opponent to nitrosative stress [3] Methylcobalamin (functions in the cell plasma as a coenzyme in the methylation cycle) and 5-deoxyadenosylcobalamin (functions in the mitochondria as a coenzyme in the citric acid cycle) are the metabolically active forms of vitamin B12

Consult your GP to assess whether symptoms are genuinely related to the supplement and discuss alternative formulations if needed