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As of January 2025, efgartigimod is the only FcRn antagonist with registered (albeit in not all cases ongoing) trials within bullous pemphigoid, post-coronavirus disease 2019 (COVID-19) postural orthostatic tachycardia syndrome, membranous nephropathy, and antineutrophil cytoplasmic antibody-associated vasculitis, and disclosed development plans detail an investigation of efgartigimod within more than ten indications [245]

The protection against overdose death was unforeseen but clearly of enormous potential clinical benefit. The study was published this week online ahead of print in the journal ACS Chemical Biology

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These compounds penetrate the BBB in sufficient quantity to facilitate memory consolidation and retrieval in aged rats, and the scopolamine-induced amnesic rat model of AD, as measured employing the Morris water maze task of spatial memory [80]

Lamin B1 fluctuations have differential effects on cellular proliferation and senescence