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One study systematically demonstrated the feasibility of probiotics and prebiotics regulating OP via the brain-gut-bone axis, particularly emphasizing the central roles of SCFAs, intestinal barrier repair, and immunomodulation, with their efficacy corroborated by both animal experiments and human clinical data (263)

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In our study, bone age, target height, and height velocity before the examination were similar between the GHD and non-GHD groups

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