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Medicare Part A and Part B may cover B12 shots if a doctor deems it medically necessary Medicare Part D is unlikely to cover B12 shots or oral supplements unless you can get it approved with a plan utilization management program B12 shots are used to treat a severe B12 deficiency that causes health issues such as fatigue and weakness, anemia, constipation, and more Does Medicare cover B12 shots

However, the lack of human clinical trials means long-term safety in people remains unknown