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Thus, diet derived and drug- derived antioxidants may be important in providing protection and treatment for a number of diseases

For instance, combining GSH-targeted delivery with chemotherapy, radiotherapy, or immunotherapy can produce synergistic anticancer effects

This indicates substantial phenotypic heterogeneity and suggests that metabolic factors likely act as potent disease accelerants in genetically or biomechanically susceptible individuals, rather than being universal initiators (34)

Factors like environmental toxins, poor diet, and aging can deplete glutathione levels, leading to potential health risks

Despite the development of these novel therapies, radiation therapy remains a critical tumor treatment 4,5