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Determining the correct dosage of protein is vital for overcoming the catabolic state of chronic illness

Increased plasma xanthine and hypoxanthine can also occur consequent to disorders of mitochondrial oxidative phosphorylation or of glycogen metabolism (77)

HIF-1 has also been shown to activate transcription of genes encoding inducible nitric oxide synthase and heme oxygenase-1 (which are responsible for the synthesis of the vasoactive molecules NO and CO, respectively), as well as the gene encoding transferrin (which, like EPO, is essential for erythropoiesis) [52, 53]

This may include antihistamines to ease itching, corticosteroids to reduce inflammation, or epinephrine for more serious symptoms