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It is formed from another highly reactive ROS called superoxide ( O2- )

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Fxr2 in adipocytes derived from stem cell-derived exosomes (ADSC-Exos) regulate the expression of ATF3/SLC7A11, effectively reducing the susceptibility of M2 microglia to ferroptosis

doi:10.1172/jci33680

In consensus, an accumulation of mitochondrial DNA (mtDNA) mutations, increased mitochondrial oxidative stress and a decrease in mitochondrial energy metabolism are all important contributors to aging (Lee and Wei, 2012)