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Clinical trials have used doses of 25-30 nmol/kg by IV infusion (Schneider-Helmert et al., 1981Subcutaneous administration and oral intestinal absorption have also been studied

Lacking BTK is related to impaired macrophage function, TNF- production, and FR-dependent mast-cell degranulation

These mediators contribute to systemic inflammation that has been strongly implicated in asthma pathophysiology [41]