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By advancing the accuracy and scalability of in vitro liver models, this work contributes to reducing reliance on animal testing and promoting ethical innovation in preclinical research, as emphasized by Ingelman-Sundberg and Lauschke 43

The gut microbiota plays a significant role in this process by facilitating the reduction of bilirubin to urobilinogen

It protects cells from oxidative stress and supports mitochondrial function

(2013) 4:e660

Conclusion and perspectives: towards a systems-level understanding of proteostasis Over the past decade, proteostasis research has evolved from studying isolated degradation pathways to appreciating a deeply interconnected, adaptive, and dynamic cellular defense network