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Creatinine levels above 1.2 mg/dL in women and 1.4 mg/dL in men indicate reduced filtration, while protein in urine (proteinuria) often appears before other symptoms

This makes injectable supplementation a reasonable approach for anyone with confirmed or suspected absorption problems, though it does not prove the combination provides benefits beyond separate administration

Newer strategies involving TKI treatment to the point of maximal response followed by local consolidative treatment are under investigation 322325 as are upfront combinations of targeted agents with chemotherapy in patients with advanced-stage disease 326

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[DOI] [PubMed] [Google Scholar] 90.Shim D., Bae I.-H., Chung J.-O., Mok H.-W., Roh J., Kim W., Lee S