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Receptor-mediated transcytosis (RMT): It is the most common route exploited for delivering chemotherapeutic agents into the brain using the vesicular trafficking machinery of endothelial cells, as well as for the entry of NPs (Figure 3D) (Van Rooy et al., 2011

BDNF = brain-derived neurotrophic factor, TrkB = tropomyosin receptor kinase B, HGF = hepatocyte growth factor, c-met = c mesenchymal-epithelial transition factor

Gransson, O., Kopietz, F

These limitations have contributed to the lack of conclusive clinical efficacy observed to date (Kurkinen, 2023)

Hormone replacement therapy has been shown to mitigate some of these immunological alterations