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We also conducted a systematic review of primary studies on the benefits and harms of e-cigarettes for smoking cessation that identified 17 randomized controlled trials (RCTs) and 1 cohort study,23 which we compared with a Cochrane living systematic review on e-cigarettes24 in January 2025

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But below harmful isnt the same as zero, and theres no proven benefit to ionization that justifies any ozone exposure for respiratory-compromised individuals