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While this groups work is peer-reviewed and published in indexed journals, the absence of independent replication by unaffiliated research teams is a significant limitation

This prevents learning individual response at lower amounts and wastes product if lower doses would suffice

Nevertheless, many reports exhibited small sample sizes, incomplete particle characterization, and variable exposure protocols, which may affect reproducibility

Bioactive compounds Bioactive compounds are essential compounds found in nature, including polyphenols, flavonoids, alkaloids, fatty acids, polysaccharides, vitamins, and carotenoids

That is not inherently problematic, but it shifts the accountability burden