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Oxidative DNA stress occurring after cerebral ischemia is associated with a decrease in apurinic/apyrimidinic endonuclease/redox factor-1 (APE/Ref-1) expression (Fujimura et al., 1999)

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Typical COA elements to request: sequence confirmation, HPLC % purity, MS confirmation (m/z), and endotoxin (EU) where applicable Retention time and peak purity information on HPLC chromatograms Manufacturing environment and batch traceability documentation Storage and handling recommendations included with each lot Batch Consistency Consistent synthesis and purification parameters across batches are critical for reproducible experiments