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5 Future directions The clinical load of neurodegenerative diseases like AD and PD is projected to increase exponentially in coming years, with a commensurate increase in need for potential treatments

Further evidence of hypercortisolemia decreasing GH and increasing IGF-I comes from data of exogenous glucocorticoid therapy in humans

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Additional oral supplementation with polypodium leucotomos extract (PLE) at 480 mg twice daily can be helpful (anecdotal evidence, unpublished)

Stacking and Synergy One of the most intriguing findings in the weight-loss peptide space is the synergy between Cagrilintide and GLP-1 agonists