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Although multiple reports provide evidence that oxidative stress markers unequivocally decrease in metformin-treated patients, the molecular targets have not been comprehensively determined

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5.2 The relationship between migraine and neurogenic inflammation 5.2.1 Clinical evidence of neurogenic inflammation Increased blood expression of cytokines has been reported in migraineurs, both adults and children

Furthermore, PCs can inhibit the release of inflammatory factors, thereby alleviating the inflammatory response in the skin and consequently slowing its aging process (30, 31)

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