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However, this impairment was not observed in BMDMs in which RIPK3 was knocked down, indicating that PGAM5 promotes inflammasome activation independent of RIPK3 (ref

Gay CM, Stewart CA, Park EM, Diao L, Groves SM, Heeke S, Nabet BY, Fujimoto J, Solis LM, Lu W, Xi Y, Cardnell RJ, Wang Q, Fabbri G, Cargill KR, Vokes NI, Ramkumar K, Zhang B, Della Corte CM, Robson P, Swisher SG , Roth JA, Glisson BS, Shames DS, Wistuba II, Wang J, Quaranta V, Minna J, Heymach JV, Byers LA

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Individual nutritional needs vary based on age, health status, and other factors