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Insulin resistance can lead to reduction in ammonium production in the renal proximal tubule resulting in lower urine pH 41

In contrast, daily administration of l-carnitine (200 mg/kg/day) for 28 successive days resulted in a significant 84% and 82% increase in AMPK-2 level in serum and cardiac tissues, respectively, as compared to the control group

Conversely, when the demand for NADPH increasessuch as during fatty acid synthesis, cholesterol synthesis, or detoxification of reactive oxygen species (ROS)the levels of NADP+ rise, relieving the inhibition on G6PD and accelerating the oxidative phase of the PPP