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doi: 10.1126/science.1251141

doi: 10.1186/s42269-019-0227-2 42 PasareCMedzhitovR

In addition to GSH, cysteine metabolism produces reactive sulfur species such as hydrogen polysulfides (H 2 S n ), which can act as nucleophilic and redox-active metabolites scavenging reactive oxygen species and lipid peroxyl radicals, thereby mitigating lipid peroxidation independently of the GPX4GSH axis [77,78]