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Although the matched estimates remained directionally consistent with the regression findings, the loss of statistical significance after balancing observed confounders suggests that unmeasured confounding particularly by body mass index and health motivation likely explains a substantial share of the associations detected in conventionally adjusted models

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First, as non-smokers who used snus (smokeless tobacco) have a substantially lower risk of PD, nicotine or other components of tobacco leaves have been suggested to be the mediating factor 65,66

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