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This stuff should've been done in the mid 70sthe whole research agenda was just put in deep freeze for multiple decades. In 2008 Johnson co-authored a paper entitled 'Human hallucinogen research: guidelines for safety, which outlined how to responsibly conduct medical trials with psilocybin and other hallucinogens

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We introduced a new variable called Cumulative Betel Exposure, which we calculated as the product of the number of betel quid chewed per day and the number of years betel quid was chewed