Taking large amounts of vitamin A can as well
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Participants were randomized to receive placebo or certolizumab pegol (400 mg at weeks 0, 2 and 4, followed by one of two dose schedules: 200 mg every 2 weeks or 400 mg every 4 weeks)
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This leads researchers to assume that there is a heritable component to mastocytosis as well (e.g., other genes involved).[ref][ref] In addition to KIT mutations, systemic mastocytosis also has links to mutations in the JAK2, PDGFR, NRAS, RASGRP4, CBL, IL4, TET2, and IL13 genes.[ref] MicroRNAs are also involved in the regulation of KIT expression.[ref] Interestingly, about half of all kids with cutaneous mastocytosis tend to outgrow it and go into long-term remission
