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Of these 20 genes, 12 were upregulated ( Mgst2, Aadac, Ppara, Zbtb16, Rdh7, Ugt2b5, Akr1b7, G6pc, Aldh1a1, Mgst1, Ces1d, and Fbp1 ) and 8 were downregulated ( Ifit2, Ly6a, Myadm, Cyba, Apobec2, Atf3, Anxa5, and Cfi ) in CR mice

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Precursors of monoamines, such as dopamine, serotonin, and neuroadrenaline, are produced by several members of the gut microbiota [157]