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It was observed that metabolites such as dihydroxy phenylacetic acid, butyrate, adenosine, propionate, histamine, norepinephrine, acetate, GABA, 5-hydroxy indole acetic acid, valerate, tryptophan, and aspartic acid were decreased and caproate, serotonin 3-methyl valerate, and acetylcholine were increased upon tumour growth [236]