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The dual dependence on lysosomal localization and RHEB engagement serves as a logical AND gate for a GF signal and an ample pool of biosynthetic precursors before protein synthesis and cell growth

it was synthesized by researchers at Novo Nordisk in Denmark and first described in published literature in 1998

Inert containers such as glass jars covered with Teflon-lined or high-quality polyethylene bags prevent chemical interference and contamination (Clotea et al., 2021)