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Your nicotinic receptors downregulate their sensitivity after days to weeks of consistent exposure, dampening acute vasoconstrictive responses

I AM talking about pure nicotine, not nicotine plus the thousands of other toxic substances designed to keep people hooked on cigarettes

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One study, for example, treated Sprague Dawley rats treated with gestational nicotine (3 mg/kg/day) and found that PNE offspring (P35/P36) had altered myelin expression of myelin-related transcription and trophic factors that produced alterations in myelin gene expression and oligodendrocyte functioning [165]

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