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Moreover, the microbiome of animals grown in laboratory conditions and nature may vary greatly, affecting the potential response to drug therapies (Ramos et al

van Geldermalsen M, Wang Q, Nagarajah R, Marshall AD, Thoeng A, Gao D, et al

For IBS-C, first-line options include polyethylene glycol, linaclotide, plecanatide, and tenapanor

Because they target different receptors (GHRH vs

Recent work has highlighted persistent challenges in metabolomics and ML-based biomarker discovery, including variability in sample preparation, platform-dependent effects, and the risk of overfitting in high-dimensional datasets 76,77