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The combination of phototherapy with local treatment has proven to be our most effective approach." Dermatology Clinic Dermanat Where Vitiligo Responds Best to UVB Therapy Face & Neck Very high success Arms & Torso Good response Hands & Feet Slower repigmentation Hair Areas Moderate response Vitiligo on the face and neck often repigments the fastest because hair follicles contain melanocyte stem cells that help restore pigment

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ROS and RNS can interact with DNA, causing base modifications, single- and double-strand breaks, and cross-linking

These cyclic processes are regulated primarily by the hypothalamuspituitaryovary axis

ScGrx7 is particularly suited for unbiased kinetic and mechanistic studies because of its high activity, the absence of ironsulfur clusters in enzyme preparations and the lack of additional cysteine residues 11 (glutaredoxins with two or more cysteine residues have complex kinetics because of alternative redox states and reactions 10,12,14,17,30,31,32,33 )