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In some embodiments, the otic formulation or composition comprises between about 0.10% to about 5% by weight of the therapeutic agent, or pharmaceutically acceptable prodrug or salt thereof

GLP3 peptide was engineered from a GIP peptide backbone to simultaneously activate GLP-1, GIP, and glucagon receptors, while Cagrilintide peptide is a modified amylin analog designed with enhanced stability to resist the fibrillation that makes native amylin challenging to work with

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Alzheimer patients typically present with low IGF-1 and GH levels