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Recent research has focused on the metabolic role of the intestine via exploring incretins, such as GLP-1 10,11 , microbiome 12,13 and gut-derived peptides 10,14
What this means for clinical research: Clinical development in 2026 is increasingly geographically modular, requiring sponsors and CROs to coordinate multi-region strategies earlier and manage data, quality, and regulatory alignment across jurisdictions
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279 Furthermore, aging can drive oxidative stress, 280 DNA damage, 281 epigenetic modifications, 282 and mitochondrial dysfunction, 283 which can also contribute to the accumulation of A plaques and tau tangles
It correlates with basicity, which measures the extent to which a molecule with lone pairs can react with an acid (Bronsted or Lewis)
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