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Tirzepatide already covers GLP-1 (so semaglutide adds redundancy)

[2] The bar for FDA drug approval is extremely high, and many compounds that fall short of that bar still have meaningful clinical utility under medical supervision

It has also been used to treat premature ejaculation, chronic depression, pancreatitis, Parkinsons disease, and AIDS myelopathy

& Tang, T

Somatic symptoms of anxiety related to the digestive tract activity include, among others, dry mouth, burning in the esophagus, heartburn, excessive salivation, nausea and vomiting, spastic states of the esophagus, stomach, and intestines, a feeling of discomfort in the abdominal cavity, diarrhea, functional motility disorders, swallowing problems, lack of appetite, and sometimes excessive appetite and obesity