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Avoid rubbing the area, but you can lightly massage it if your provider recommends it

From Rat Studies to Human Extrapolation From rat studies, the remarkably consistent effective dose range of 0.0045 mg/lb to 0.0000045 mg/lb intraperitoneally (a 1000-fold range showing similar efficacy) worked across depression, anxiety, Parkinsons, stroke, schizophrenia, and seizure models

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10.1016/j.molimm.2018.10.016 122 HuangJ.-Y.PengS.-F.ChuehF.-S.ChenP.-Y.HuangY.-P.HuangW.-W.et al (2021)