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If you experience nausea that disrupts eating or daily life, hold the current dose for an extra week

In addition, the iron-containing metal-organic framework TPL@TFBF is formed through the coordination of tannic acid (TA) with Fe + , loaded with triptolide (TPL) and coated with FA-modified BSA, among them TPL increases intracellular ROS production by inhibiting the expression of Nrf2, leading to ferroptosis and pyroptosis, releasing a large amount of DAMPs, which in turn stimulates DCs antigen presentation and CD4 + /CD8 + T cell proliferation thereby suppressing tumor growth and metastasis (227)

However, challenges remain, including standardization, herb-drug interaction studies, large-scale clinical trials, and regulatory harmonization

Sweeney MD, Sagare AP, Zlokovic BV (2018a) Blood-brain barrier breakdown in Alzheimer disease and other neurodegenerative disorders

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