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In G6PD-deficient patients, liver vulnerability is often expected due to the low concentration of G6PD enzymes and high oxidative stress in hepatocytes

doi: 10.1016/j.cmet.2015.12.006 8 LongJPLiXNZhangF

Some studies suggest that it may have a modest effect on reducing waist circumference and body weight, but others find no significant difference compared to a placebo

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As oxidative stress increases, further stimulation of pro-inflammatory cytokines such as TNF- and IL-1 increases and contributes to synaptic dysfunction and neuronal degeneration ( These studies suggest that the loss of antioxidant defense is an early biochemical event rather than a late-stage consequence of neuronal death