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The Journal of Biological Chemistry 277(6): 4223-4231

El-Hattab, AW, Adesina, AM, Jones, J, Scaglia, F 2015, MELAS syndrome: Clinical manifestations, pathogenesis, and treatment options, Molecular genetics and metabolism , vol

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doi: 10.1161/CIRCRESAHA.119.315939 138 ZhangXHouLGuoZWangGXuJZhengZet al

Nevertheless, some drawbacks such as derivatization, cumbersome laboratory procedures, time consumption and applicable feasibility in vivo were not conducive to the development of a practical method