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In clinical use, children with extensive thermal burns who were treated with IGF-I in combination with IGFBP-3, presented a reduction in serum levels of IL-1, TNF-, C-reactive protein, 1-acid glycoprotein, and complement C-3[299]

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Studies have shown that great than 20% concentration does not increase the benefits and may cause irritation

In parallel, the fracture behavior of AA2024-T3 is evaluated through notch tension, shear, and central-hole specimens, with strain fields monitored using digital image correlation (DIC)