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The most commonly reported adverse effects in clinical trials are gastrointestinal in nature, particularly during dose escalation

Aseptic technique, when combined with safe, sterile equipment, is essential for patient safety

Indeed, thyroid dysfunction is the most frequent endocrine irAE and may affect up to 40% of patients receiving ICIs (Baraka et al

American Heart Association (2025)

More recently, a multi-layered and single-cell transcriptome analysis of Schwann cells and the full sciatic nerve revealed that cortistatin and its receptors are expressed not only in Schwann cells but also in other cells of the sciatic nerve, including pericytes, epineurial, endothelial, and immune cells [86]