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Tomatidine alleviates intervertebral disc degeneration by activating the nrf2/ho-1/gpx4 signaling pathway

Mfn-2 interacts with the ER-resident protein inositol-requiring enzyme 1 (IRE1) to participate in arsenic-induced ferroptosis, while IRE1 also influences ferroptosis sensitivity by regulating GSH synthesis (67)

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This work has for the first time reported that Glu is able to enhance the heat tolerance of maize seedlings by activating GLRs-mediated calcium signaling, but the detailed physiological and molecular mechanisms need to be further explored in the future