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Current limitations include the complexity of the mechanisms of action, which makes it difficult to identify predictive biomarkers of response, the lack of detailed pharmacokinetic data for synthetic TB-500, and the difficulty of translating effective doses from animal models to humans

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Synthesized peptides have been used in medicine as pharmaceuticals for decades, says endocrinologist Rekha Kumar, MD, associate professor of clinical medicine at Weill Cornell Medicine in New York City