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The National Institutes of Health (NIH) highlight its role in DNA production, red blood cell formation, and nervous system health

J Palliat Med 2009;12(4):359362

In summary, the key interactions to consider are pyridoxines reduction of levodopa and anticonvulsant efficacy, niacinamides additive effects on blood pressure, blood sugar, and gout management, and the potential need for B-vitamin repletion in patients on certain medications (diuretics, isoniazid, etc.)

The authors commented that these results suggest that T4 is a potent wound healing factor with multiple activities