The authors reported that intra-articular AOD-9604 injection in the rabbit osteoarthritis model produced macroscopic, histologic, and biomechanical evidence of cartilage preservation relative to untreated controls, with the combination of AOD-9604 plus hyaluronic acid yielding the most consistent chondroprotective effect [4]
All subjects were enrolled in a standard wound care protocol, where only the subjects with sharp ulcer wound or debridement were entered into this randomized, placebo controlled clinical trial
In addition, mice were also administered with 100 g of the SAM-FVpE or SAM protein in 500 l PA adjuvant containing lycium barbarum polysaccharide (20g/mL) and chitosan (1%, w/w)
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