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Substance abuse often stems from a combination of factors: Genetics: A family history of addiction increases susceptibility

Unlike cigarette testing machines, which were calibrated to smoke the putative reduced-risk cigarettes in a standardised way, smokers compensated for the lower delivery of nicotine by taking more and deeper puffs per cigarette, smoking more and occluding the tiny ventilation holes on the filters with their fingers

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That makes them narrower, and it makes it more difficult for your heart to pump blood through them